核医学简史 感染的成像成像
1Department of Radiology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
核医学已经发展为感染诊断,从-67酸转向标记白细胞和18F-FDG. 目前的药物检测宿主反应,推动针对感染的成像药物的研究.
科学领域:
- 核医学就是核医学.
- 感染成像 感染成像
- 放射性药物开发 放射性药物开发
背景情况:
- 近50年来,核医学对感染诊断至关重要.
- 早期的药物,如-67酸盐具有局限性,促使开发替代品.
- 标记白细胞成像和18F-FDG已经变得很重要,但检测宿主反应,而不是直接感染.
研究的目的:
- 审查核医学成像剂用于感染诊断的演变.
- 要突出当前成像模式的局限性.
- 为了强调对特定感染的成像剂的持续需求.
主要方法:
- 审查历史和当前的核医学成像技术的感染.
- 讨论放射性药物,包括-67酸盐,-111和-99m标记白细胞,以及18F-FDG.
- 分析现有代理商的优缺点.
主要成果:
- -67酸盐曾经是主要的药剂,现在使用范围有限.
- 尽管存在缺点,但体外标记白细胞成像仍然很重要.
- 18F-FDG对各种感染和疾病有价值,但不是特定于感染的.
结论:
- 尽管取得了进展,但目前的核医学感染剂主要反映了宿主反应.
- 在开发体内白细胞标记和感染特异性剂方面仍然取得了有限的成功.
- 持续的研究对于开发真正针对感染的核医学成像剂至关重要.
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