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使用18F-化氧sorbitol正子发射断层扫描仪对瘤向细菌进行成像

Alvaro A Ordonez^1,2, Falk Saupe³, Christoph A Kasper³

¹Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

The Journal of infectious diseases

|October 3, 2023

概括

18F-Fluorodeoxysorbitol (18F-FDS) PET成像在小鼠乳腺癌模型中成功可视化了Yersinia enterocolitica. 这种针对细菌的成像方法可以帮助开发微生物癌症疗法.

科学领域:

在瘤学瘤学.
微生物学微生物学
医疗成像医学成像

背景情况:

基于微生物的癌症治疗是一种新兴的治疗策略.
在瘤中的细菌殖民需要有效的成像用于开发和临床转化.
非侵入性,细菌特异性成像可以评估瘤和非目标殖民.

研究的目的:

评估18F-Fluorodeoxysorbitol (18F-FDS) 定子发射断层扫描 (PET) 用于可视化细菌特异性癌症治疗.
在使用Yersinia enterocolitica的小鼠乳腺癌模型中评估18F-FDS PET的实用性.

主要方法:

在小鼠乳腺癌模型中使用了一种衰减的Yersinia enterocolitica菌株.
18F-FDS PET被用于可视化直接内或静脉注射后的细菌殖民.
使用18F-化氧糖 (18F-FDG) PET作为比较成像方式.

主要成果:

在实验室中,Yersinia enterocolitica显示出极好的18F-FDS吸收.
与未殖民瘤相比,18F-FDS PET在殖民瘤中显示出明显更高的信号.
在殖民和未殖民瘤之间没有观察到18F-FDG PET信号的显著差异.

结论:

18F-FDS PET是一种可行的细菌特异性成像方法.
这种方法可以支持基于Yersinia enterocolitica的癌症治疗方法的开发和临床转化.
18F-FDS PET可以作为管理接受微生物治疗的癌症患者的补充工具.

关键词:

免疫疗法免疫疗法基于套件的合成.在安全方面,安全是安全的.翻译工作的翻译工作.

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