抗甲状腺药物及其类型的氧化,由ABTS基离子激素氧化
Bożena Frąckowiak-Wojtasek1, Beata Gąsowska-Bajger1, Damian Tarasek1
1Institute of Chemistry, Opole University, Ul. Oleska 48, 45-052 Opole, Poland.
Bioorganic chemistry
|October 3, 2023
概括
抗甲状腺药物的类型对抑制活性进行了测试. 这些化合物减少了ABTS基,这表明除了直接减少过氧化之外,还有一种抗甲状腺作用的机制.
科学领域:
- 生物化学 生物化学
- 内分泌学 在内分泌学.
- 药用化学 医学化学
背景情况:
- 乳氧化酶 (LPO) 和2.2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) 测定是评估抗氧化活性的既定方法.
- 抗甲状腺药物及其类型正在研究潜在的治疗应用.
- 抗氧化剂在甲状腺激素产生中的作用和潜在的抑制机制是目前正在积极研究的领域.
研究的目的:
- 使用LPO-ABTS系统研究抗甲状腺药物的类型的抑制活性.
- 探索这些化合物的作用机制,特别是关于它们与活性氧物种的相互作用.
- 评估这些化合物干扰甲状腺过氧化酶活性和激素合成的潜力.
主要方法:
- 使用乳酸氧化酶和ABTS作为基质的酶抑制试验.
- 通过抗甲状腺药物及其类型的ABTS基性减少的光谱光度监测.
- 对反应产物和中间体的分析,包括酸和物种.
主要成果:
- 抗甲状腺药物 (propylthiouracil,methimazole) 和它们的类型药物有效地减少了ABTS基.
- 甲基马的类型在LPO的ABTS氧化过程中对过氧化消耗产生中度影响.
- 1-Methylimidazole-2-selone及其脱化物形成了稳定的酸,而1,3-dimethylimidazole-2-selone则直接产生了.
结论:
- 抗甲状腺药物的类相应物减少ABTS激素表明其抗甲状腺作用的潜在机制,可能是通过清除参与甲状腺激素合成的激素.
- 直接减少过氧化不太可能是这些化合物的观察到的抑制作用的主要机制.
- 在ABTS基的存在下,不同类型的不同化学行为凸显了化学结构在确定它们的反应性和潜在生物活性方面的重要性.
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