瓦雷尼克林用于戒烟的有效性和安全性:概述和元分析
Xue Shang1, Fenfen E, Kangle Guo
1From the Health Technology Assessment Center/Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, China (XS, FE, KG, CY, LZ, YW, KY, XL); Gansu Provincial Hospital, Lanzhou, China (KG); Evidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China (XS, FE, KG, CY, LZ, YW, KY, XL); Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou, China (XS, FE, CY, LZ, YW, KY, XL).
瓦伦尼克林在戒烟方面比安慰剂更有效,经过元分析和试验序列分析证实了这一点. 副作用通常是轻度至中度,并且耐受良好.
科学领域:
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 临床医学 临床医学
背景情况:
- 吸烟仍然是全球可预防死亡的主要原因之一.
- 有效的药物治疗对于帮助戒烟至关重要.
- 瓦伦尼克林是一种广泛用于戒烟的药物.
研究的目的:
- 评估瓦伦尼克林在戒烟方面的疗效和安全性.
- 综合系统性审查和随机对照试验的证据.
- 用元分析和试验顺序分析来确认发现.
主要方法:
- 进行了概述,元分析和试验顺序分析.
- 包括13项系统性审查和46项随机对照试验.
- 使用推,评估,开发和评估等级的方法评估证据质量.
主要成果:
- 与安慰剂相比,瓦伦尼克林显著增加了戒烟的几率 (OR = 2.54).
- 在患有疾病的吸烟者和普通吸烟者之间,以及随访时间之间,有效性有所不同.
- 常见的不良事件包括恶心,异常的梦想和头痛;事件轻度至中度.
结论:
- 瓦伦尼克林在戒烟方面比安慰剂表现出优越性.
- 尽管有轻度至中度的不良事件,但药物通常被很好地容忍.
- 未来的研究应该探索组合疗法和比较有效性研究.
更多相关视频
09:30A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol
Published on: January 18, 2018
06:39Electroencephalographic, Heart Rate, and Galvanic Skin Response Assessment for an Advertising Perception Study: Application to Antismoking Public Service Announcements
Published on: August 28, 2017
相关概念视频
Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
Stimulants
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Dose-Response Relationship: Potency and Efficacy
CNS Depressants: Alcohol and Nicotine
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
Two synthetic agonists of THC,...
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
