腹腔透析患者的自主神经系统功能障碍:一个未被认可的心血管风险因素?
Danai Faitatzidou1, Artemios G Karagiannidis1, Marieta P Theodorakopoulou1
1First Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
American journal of nephrology
|October 3, 2023
概括
自主神经系统 (ANS) 功能障碍在患有末期脏疾病 (ESKD) 的腹透析 (PD) 患者中很常见. 这种功能障碍与这种脆弱人群中心血管风险和死亡率的增加有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 自主神经科学 自主神经科学
背景情况:
- 心血管事件是末期病 (ESKD) 患者接受腹腔透析 (PD) 的首要死亡原因.
- 自主神经系统 (ANS) 功能障碍是公认的非传统风险因素,有助于该人群的心血管负担.
- 在PD患者中, ANS 功能障碍背后的复杂病理生理机制尚未完全理解.
研究的目的:
- 阐明ESKD和PD患者ANS功能障碍的发病机制.
- 审查和总结现有研究,评估PD患者的ANS功能障碍.
- 突出ANS功能障碍作为PD心血管风险因素的作用.
主要方法:
- 关于在PD患者中调查ANS功能障碍的研究的文献综述.
- 分析ESKD,PD和ANS功能障碍之间的病理生理机制.
- 综合证据将ANS功能障碍与PD患者的临床结果联系起来.
主要成果:
- 预先的研究证实了在PD患者中存在ANS功能障碍.
- 队列研究表明ANS功能障碍与不良临床结果之间存在联系.
- ANS功能障碍越来越被认为是PD的独立心血管风险因素.
结论:
- 患PD患者的ANS功能障碍是由多种复杂的机制引起的,这些机制破坏了交感/副交感 (SNS/PNS) 平衡.
- 这种干扰是PD患者心血管发病率和死亡率的关键调解者.
- 进一步的研究是有必要的,以充分理解和管理在这个人群中的ANS功能障碍.
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