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Updated: Jul 15, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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表观遗传平衡确保了MLL放大和重排的机械控制

Zach H Gray1, Damayanti Chakraborty2, Reuben R Duttweiler3

  • 1Cancer Epigenetics Institute, Fox Chase Cancer Center, Philadelphia, PA 19111, USA; Nuclear Dynamics and Cancer Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

Cell
|October 3, 2023
PubMed
概括

在白血病中表观遗传调节器控制MLL/ KMT2A放大和重组. 基因组甲基化平衡和MLL/KMT2A位点的CTCF占用是关键,提供潜在的药物标.

关键词:
在CTCFDNA放大G9a 其他H3K9me 其他在KDM3B其他国家美国多克索鲁比辛ecDNA 在进行调整

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