在患有慢性静脉功能不全的患者中评估动态醇/二硫化物恒温
Ayhan Muduroglu1, Yusuf Velioglu1, Humeyra Celik2
1Department of Cardiovascular Surgery, Bursa City Hospital, Bursa, Turkey.
Journal of vascular surgery. Venous and lymphatic disorders
|October 3, 2023
概括
这项研究表明,慢性静脉功能不全患者的动态醇/二硫化物恒温有所改变,这表明氧化应激增加. 这一发现表明,醇/二硫化物平衡可以作为这种疾病的新生物标志物.
科学领域:
- 生物化学 生物化学
- 血管医学 血管医学
- 氧化压力研究研究 氧化压力研究
背景情况:
- 慢性静脉功能不全 (CVI) 是一种具有复杂病理生理学的普遍疾病.
- 氧化应激与CVI的进展有关,但缺乏特定的生物标志物.
- 动态醇/二硫化物恒温尚未在CVI患者中进行过研究.
研究的目的:
- 研究动态醇/二硫化物恒温作为慢性静脉不全患者中氧化应激的潜在指标.
- 为了比较CVI患者和健康对照者之间的醇/二硫化物平衡参数.
主要方法:
- 一项前性病例控制研究,涉及80名CVI患者 (CEAP C3-C6) 和80名健康对照.
- 测量了白蛋白,铁氧化酶,髓氧化酶,原生硫醇,总硫醇和二硫化物的血清水平.
- 计算了动态醇/二硫化物恒温参数 (比率),并在各组之间进行了比较.
主要成果:
- 在CVI患者和对照人群中,人口和临床特征相似.
- 血清铁氧化酶和髓氧化酶水平在CVI患者中显著更高.
- 与对照组相比,CVI患者的专蛋白,原生硫醇,总硫醇和二硫化物水平显著较低.
结论:
- 在患有慢性静脉功能不全的患者中,动态醇/二硫化物稳态显著受到干扰.
- 改变的醇/二硫化物平衡反映了CVI中氧化应激增加.
- 这种稳态可以作为评估CVI中氧化应激的新生物标志物.
相关概念视频
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
14
The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
14
Venous Thrombosis IV: Nursing Management
14
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
14
Assessment of the Cardiovascular System III: Palpation
369
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
369
Venous Thrombosis I: Introduction
12
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
12
Varicose Veins II: Diagnostic Studies and Interprofessional Care
14
Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
14
Venous Thrombosis III: Interprofessional Care
10
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
10


