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抗生素耐药性基因的危险风险:宿主发生,分布,移动性和从不同的环境向玉米料的垂直传播
Dongmei Xu1, Xingguo Zhang2, Xianjun Yuan3
1School of Life Sciences, Lanzhou University, Lanzhou, 730000, PR China.
Environmental pollution (Barking, Essex : 1987)
|October 3, 2023
概括
抗生素耐药性基因 (ARG) 是玉米料中发现的一种公共卫生风险. 虽然它们的数量在化过程中减少,但了解化中的ARG对于生物安全至关重要.
科学领域:
- 环境微生物学环境微生物学
- 公共卫生 公共卫生
- 食品安全 食品安全
背景情况:
- 抗生素耐药性基因 (ARG) 是一种重要的新兴污染物,具有重大公共卫生影响.
- 玉米料是一种广泛使用的动物料,可能含有ARG,需要对其流行情况和潜在风险进行调查.
研究的目的:
- 在中国不同气候区的全作物玉米料中研究抗生素耐药性基因 (ARG) 的多样性和丰富性.
- 评估与料中的抗生素耐药性及其垂直转移相关的潜在风险.
- 了解ARG,微生物组成和料中的发酵特征之间的关系.
主要方法:
- 用转基因组分析来描述玉米料样本中的抗生素耐药性.
- 从中国六个不同的气候区采集了样本,使用Köppen-Geiger系统进行分类.
- 分析包括识别主导的ARG,高风险的ARG及其细菌宿主,以及跟踪化过程中的变化.
主要成果:
- 检测到ARG的多样性很高,特别是那些对四环素,西普罗素,林科萨米德,斯福米辛和β-乳糖抗生素产生耐药性的抗生素.
- 主导的ARG包括tetM,acrA,H-NS,lnuA,emrR和KpnG,主要由克莱布西拉和乳杆菌作为宿主.
- 在90天的化过程中,ARG和移动ARG的丰度显著下降,在西藏料中观察到的污染程度较低.
结论:
- 玉米料含有多种抗生素耐药性,构成潜在的生物安全风险.
- 环境因素和料发酵影响ARG的丰度和组成.
- 虽然确保降低了ARG负载,但持续监测ARG,它们的宿主和料中的移动遗传元素对于减轻公共卫生风险至关重要.
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