非白人固体器官移植患者的皮肤癌:梅奥诊所的经验
Daniel Zieman1, Michael Heckman1, Danielle Brushaber1
1From the Department of Dermatology, Mayo Clinic in Florida, Jacksonville.
Southern medical journal
|October 3, 2023
概括
固体器官移植接受者 (SOTRs) 的皮肤癌风险更高. 这项研究详细介绍了非白人SOTR的皮肤癌发育模式,发现了各种癌症类型和种族背景.
科学领域:
- 在瘤学瘤学.
- 移植医学 移植医学
- 皮肤病学 皮肤病学
背景情况:
- 固体器官移植接受者 (SOTRs) 面临较高的皮肤癌风险.
- 关于非白色SOTRs皮肤恶性瘤发育的数据有限.
- 了解这些模式对于有针对性的监测和预防至关重要.
研究的目的:
- 在非白人SOTR中描述皮肤癌的模式和结果.
- 确定与这种人群中皮肤癌发展相关的移植前和移植后因素.
主要方法:
- 在梅奥诊所对非白色SOTR的回顾性图表审查.
- 从1987年11月到2020年4月收集的数据.
- 对患者人口统计,移植史和皮肤癌类型的分析.
主要成果:
- 32名非白人SOTR在移植后患上皮肤癌.
- 西班牙裔/拉丁裔 (46.9%),美国印第安人/阿拉斯加本土人 (25%),亚洲人 (21.9%) 和黑人/非洲裔美国人 (6.3%) 代表了这些族群.
- 状细胞癌 (65.6%) 和基底细胞癌 (46.9%) 是最常见的;黑色素瘤 (15.6%) 和脂质癌 (6.3%) 也发生.
- 移植后皮肤癌发病的中位时间为7.8年.
结论:
- 这项研究描述了非白色SOTRs的皮肤癌发育情况.
- 鉴定出不同的患者人口统计和癌症类型.
- 观察到较低的发病率,与文献一致,但需要进一步研究风险因素.
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