在入侵性机械通风过程中通过儿科肺模型中的直线肺内冲击通风进行阿尔布特罗尔的输送
Ariel Berlinski1, L Denise Willis2
1Department of Pediatrics, University of Arkansas for Medical Sciences, College of Medicine, Little Rock, Arkansas; Pediatric Aerosol Research Laboratory, Arkansas Children's Research Institute, Little Rock, Arkansas; and Respiratory Care Services, Arkansas Children's Hospital, Little Rock, Arkansas. BerlinskiAriel@uams.edu.
Respiratory care
|October 3, 2023
概括
在机械通风过程中使用直线肺内冲击式通风 (IPV) 装置输送阿尔布特罗尔是低效的. 在儿科患者中,应考虑使用IPV的替代性吸入药物输送方法.
科学领域:
- 儿科重症监护医药 儿科重症监护医药
- 呼吸系统疗法 呼吸系统疗法
- 药理动力学 药理动力学
背景情况:
- 机械通风通常需要空气通道清除和吸入疗法.
- 肺内冲击式通风 (IPV) 结合了高频通风器和雾化器.
- 关于IPV设备的气溶传递效率的数据有限.
研究的目的:
- 为了评估IPV在线适配器的阿尔布特罗尔输送效率.
- 评估各种条件在侵入性机械通风过程中对气溶输送的影响.
主要方法:
- 使用了模拟侵入性机械通风的儿科肺部模型.
- 独立变量包括肺部状况,呼吸机模式,适配器打开,IPV设置和内管大小.
- 测量Albuterol的输送效率是指在内肌管尖端捕获的负载剂量的百分比.
主要成果:
- 阿尔布特罗尔的输送效率在0%至2.89%之间,中位数为0.54%.
- 适配器的开放率 (R2=0.30) 和IPV设置 (R2=0.039) 是影响交付效率的主要因素.
- 整体模型匹配 (R2=0.363) 表示所有变量组合的解释能力有限.
结论:
- 在儿科模型中,在侵入性机械通风过程中通过线内IPV输送阿尔布特罗尔是非常低效的.
- 在使用IPV时,医疗保健提供者应考虑提供支气管扩展剂和其他吸入药物的替代方法.
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