扩散性肺髄膜炎:多重肺结节的罕见原因
Orla Healy1, Marissa O'Callaghan2,3, Alex Deegan4
1Department of Respiratory Medicine, St Vincent's University Hospital, Dublin, Ireland.
BMJ case reports
|October 3, 2023
概括
这项案例研究突出了扩散性肺脑膜病变 (DPM),这是一个极为罕见的肺部疾病,是多重肺结节的原因. 早期诊断需要考虑复发性呼吸道感染患者的罕见疾病.
科学领域:
- 肺部病理学 肺部病理学
- 病理学 病理学 病理学
- 放射学 放射学是一门学科.
背景情况:
- 反复出现的下呼吸道感染可能会出现扩散的肺结节.
- 肺结节的差异诊断很广泛,需要进行彻底的调查.
研究的目的:
- 描述一个扩散性肺脑膜炎 (DPM) 的病例,这是一个极为罕见的肺病.
- 强调在患有不明原因肺部发现的患者中考虑罕见诊断的重要性.
主要方法:
- 一份病例报告详细介绍了一名50多岁的女性,患有复发性呼吸道感染和多个双边肺结节.
- 诊断工作包括成像 (胸部放射,CT),支气管支气管洗,横支气管活检和视频辅助胸腔镜外科活检.
- 进行了神经细胞粘附分子 (CD56),孕激素受体,上皮膜抗原和光滑肌肉动蛋白的免疫组织化学染色.
主要成果:
- 手术活检揭示了扩散的,微小的,由无恶性细胞组成的平淡的上皮细胞组成的肠膜内结节.
- 结节对CD56和孕激素受体呈阳性染色,对表皮膜抗原和光滑肌肉活性呈弱阳性.
- 这些发现,结合临床表现,支持了扩散性肺髄膜炎 (DPM) 的诊断.
结论:
- 扩散性肺髄膜炎 (DPM) 是双边扩散性肺结节的极为罕见的原因.
- 这一案例强调了需要全面的差异诊断和多学科合作来评估肺部发现的必要性.
- 仔细的病史和诊断工作对于识别DPM等罕见疾病至关重要,特别是在出现呼吸道症状的女性患者中.
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