酸稳态和男性的胰岛素抵抗
Vincenzo Carnevale1, Luciano Nieddu2, Alfredo Scillitani3
1Unit of Internal Medicine, "Casa Sollievo della Sofferenza" Hospital, IRCCS, San Giovanni Rotondo (FG), Italy.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|October 3, 2023
概括
胰岛素抵抗 (IR) 与和酸盐平衡的改变有关. 患有IR男性的血清酸盐和尿路的含量较高,表明这些矿物质的处理受损.
科学领域:
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 关于胰岛素耐药性 (IR) 中 (P) 稳态存在相互矛盾的数据.
- 酸代谢对整体健康至关重要,并可能受到代谢条件的影响.
研究的目的:
- 为了研究胰岛素抵抗和没有胰岛素抵抗的男性的酸稳态参数.
- 探索胰岛素抵抗,体重指数 (BMI) 和矿物代谢之间的关系.
主要方法:
- 177名男性志愿者使用QUICKI指数进行了胰岛素耐药性评估.
- 禁食血液和点尿样本被分析为血清和尿液电解质,包括 (sCa,uCa/Cr) 和酸盐 (sP, uP/Cr).
- 用年龄调整的部分相关性来评估参数之间的关联.
主要成果:
- 与没有IR (IR-) 的男性相比,具有IR (IR+) 的男性表现出较高的血清酸盐 (sP) 和更低的尿,以肌素 (uCa/Cr) 进行校正.
- BMI与sP和副甲状腺激素 (PTH) 有积极的相关性.
- IR+组显示sP和BMI,PTH与胰岛素和UP/Cr之间有明显的相关性.
结论:
- 患有IR的男性的sP升高和uCa/Cr降低表明IR调节酸稳态.
- 这些发现表明,胰岛素抵抗可能会影响和酸盐的脏处理.
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