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Automating Aggregate Quantification in Caenorhabditis elegans
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同时选择和整合一致的外部汇总信息
Yunxiang Huang1, Chiung-Yu Huang1, Mi-Ok Kim1
1Department of Epidemiology & Biostatistics, University of California at San Francisco, San Francisco, California, USA.
Statistics in medicine
|October 3, 2023
概括
这项研究引入了惩罚性概率方法,将参与者数据与外部汇总信息相结合,即使来自不同人群. 该方法选择一致的外部数据,防止偏差并考虑采样错误.
科学领域:
- 生物统计学 生物统计学
- 流行病学 流行病学
- 健康 数据科学 数据科学
背景情况:
- 将参与者数据与外部汇总信息进行合成变得越来越重要.
- 现有的方法通常假定内部研究和外部来源之间的同质性,这很难验证.
- 违反这种同质性假设可能会导致有偏见的结果.
研究的目的:
- 开发一种被惩罚的概率方法,用于将参与者级数据与外部汇总信息合成.
- 为了解决研究群体中异质性引起的偏见.
- 提供灵活的框架,以整合来自不同来源的一致的外部信息.
主要方法:
- 建议采用惩罚性概率方法,同时选择和合成外部汇总数据.
- 该框架使用半参数密度比率模型来计算独立变量分布的差异.
- 为计算开发了一种两步估计和优化算法,解决外部数据中的采样错误.
主要成果:
- 拟议的方法有效地避免了由人口异质性引起的偏见.
- 它成功地结合了来自异质群体的一致外部信息.
- 确定了选择和估计的一致性,以及两步估计器的非对称正常性.
结论:
- 处罚概率方法为数据合成提供了一个强大的框架,克服了同质性假设的局限性.
- 这种方法提高了研究中结合多种数据源的可靠性.
- 该方法是有效地使用妊娠体重增加管理研究来说明的.
相关概念视频
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The maximum size of aggregate is defined as the aperture of the sieve retaining 15 percent or more of the particles present in the aggregate sample. The aggregate's maximum size impacts the concrete's water requirement, workability, and strength. Larger aggregates reduce the surface area needing cement paste coverage, which can lower water needs, thereby allowing a decrease in the water-to-cement ratio when the desired workability and richness of the mix are to be maintained, which can...
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Aggregate classification is generally based on its size, petrographic characteristics, weight, and source. Size classification ranges from coarse to fine aggregates, defined by the size of the particles. Coarse aggregates are particles that do not pass through ASTM sieve No. 4, and aggregates that pass through the sieve are fine aggregates.
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Deleterious substances in aggregates can be detrimental to the quality and durability of concrete. These substances include organic impurities like loam, which interfere with cement hydration and are usually present in the sand. These prevent a good bond between aggregate and cement paste. Organic impurities can be detected using the colorimetric test, where the darkness of a solution after agitation indicates the level of organic content.
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The bond between aggregate particles and the cement matrix is significantly influenced by the shape and surface texture of the aggregates. High-strength concretes benefit from a rougher texture, which leads to stronger bonding due to greater adhesion. Angular aggregates with larger surface areas also enhance this bond. The bonding quality, however, is complex to assess as no universally accepted test exists. Good bonding is indicated when a crushed concrete specimen shows some aggregate...
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