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Updated: Jul 15, 2025

Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
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PLK1通过调节酸化依赖的UHRF1蛋白稳定性来维持DNA甲基化和细胞活力

Yuchong Peng1,2,3, Youhong Liu4,5, Rirong Zheng1,2,3

  • 1Key Laboratory of Clinical Precision Pharmacy of Guangdong Higher Education Institutes, The First Affiliated Hospital, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510699, China.

Cell death discovery
|October 3, 2023
PubMed
概括

波洛基因酶1 (PLK1) 抑制通过向UHRF1蛋白稳定性来破坏DNA甲基化. 这导致瘤抑制基因表达增加和细胞活力降低,揭示了PLK1抑制剂的新抗癌机制.

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