揭示了男性发,和皮肤癌之间的复杂关系
Jue-Sheng Ong1, Mathias Seviiri2,3, Jean Claude Dusingize2
1Population Health Department, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. JueSheng.Ong@qimrberghofer.edu.au.
Nature communications
|October 3, 2023
概括
男性型发 (MPB) 与皮肤癌风险增加有关,特别是在头部和部. 这种关联主要是由于阳光照射导致头皮头发减少,而不是雄激素水平.
科学领域:
- 遗传学 遗传学 是一个
- 皮肤病学 皮肤病学
- 流行病学 流行病学
背景情况:
- 男性型发 (MPB) 与雄激素失调有关.
- 以前的观察表明MPB和皮肤癌之间存在联系,可能是由于紫外线暴露或雄激素通路.
研究的目的:
- 使用孟德尔随机化 (MR) 调查MPB和皮肤癌风险之间的关系.
- 确定雄激素或阳光照射是否是这种关联的主要驱动因素.
主要方法:
- 利用来自皮肤黑色素瘤和角质细胞癌 (KCs) 仅限男性的元分析的遗传数据.
- 进行了门德尔随机化 (MR) 分析,包括现场分层分析.
- 采用多变量模型来评估混因素.
主要成果:
- 发现MPB和KC风险之间存在强烈的关联,独立于雄激素水平.
- 确定MPB相关的单核酸多态体参与色素化通路,混了这种关系.
- 部位分层MR揭示MPB与头部和部状细胞癌和黑色素瘤有关,表明头皮暴露在阳光下是主要的驱动因素.
结论:
- MPB与皮肤癌风险之间的关联主要归因于由于头发覆盖率减少,头皮暴露于阳光的增加.
- 雄激素通路似乎不是MPB患者皮肤癌风险的主要驱动因素.
- 男性头皮毛发减少可能导致高紫外线辐射地区黑色素瘤发病率较高.
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