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Updated: Jul 15, 2025

Delivery of Modified mRNA in a Myocardial Infarction Mouse Model
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调节mRNA翻译的二次结构为ASO介导的心脏缩调节提供了洞察力

Omar M Hedaya1,2, Kadiam C Venkata Subbaiah1, Feng Jiang1,2

  • 1Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine & Dentistry, Rochester, NY, 14642, USA.

Nature communications
|October 3, 2023
PubMed
概括

在GATA4上游开放阅读框架 (uORFs) 中,一种新的双链RNA (dsRNA) 结构控制了翻译. 用反感性寡核化物 (ASOs) 准这种dRNA会改变蛋白质水平和细胞功能,提供一种新的治疗策略.

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