抑制的蓝酸免疫轴是慢性压力促进的乳腺癌进展的基础
Ling Ye1, Yuanlong Hou2,3, Wanyu Hu1
1NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China.
Nature communications
|October 3, 2023
概括
慢性压力可能会通过减少Blautia细菌和酸盐来促进乳腺癌. 恢复这些可能会增强抗瘤免疫力,并逆转小鼠癌症的进展,为患有抑郁症的女性提供潜在的治疗方法.
科学领域:
- 在瘤学中的微生物组和新陈代谢
- 免疫学和癌症研究
背景情况:
- 慢性压力是乳腺癌的一个已知的风险因素,但具体的生物机制仍然在很大程度上未知.
- 在慢性压力条件下微生物群落,代谢副产品和癌症发展之间的相互作用需要进一步研究.
研究的目的:
- 研究微生物和代谢信号在慢性压力诱导的乳腺癌进展中的作用.
- 探索蓝和酸盐对压力促成的乳腺癌和免疫反应的潜在治疗作用.
主要方法:
- 与慢性压力和乳腺癌相关的微生物和酸盐丰度的分析.
- 在压力促成的乳腺癌的小鼠模型中,对Blautia和酸盐水平的实验性操纵.
- 在治疗后评估CD8+T细胞反应和瘤进展.
主要成果:
- 在慢性压力和抑郁症的背景下,观察到Blautia细菌及其代谢物酸盐的丰度减少.
- 在小鼠中,施用Blautia和酸盐增强了CD8+ T细胞抗瘤活性,并逆转了压力诱导的乳腺癌进展.
- 患有抑郁症的人类患者的Blautia和酸盐水平较低;患有抑郁症的乳腺癌患者的酸盐水平降低,瘤透的CD8+ T细胞减少,转移风险更高.
结论:
- 蓝衍生的酸在调节对乳腺癌的免疫反应方面发挥着至关重要的作用.
- 降低酸盐水平,可能与慢性压力和抑郁症有关,可能促进癌症的进展和转移.
- 针对蓝酸轴为女性乳腺癌患者提供了潜在的治疗策略,特别是那些患有并发性抑郁症的患者.
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