慢性高血压和L-citRulline研究 (CHERRY):怀孕早期随机对照试验
Laura Ormesher1,2, Stephanie A Worton1,2, Ashley Best3
1Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
Reproductive sciences (Thousand Oaks, Calif.)
|October 3, 2023
概括
对于患有慢性高血压的孕妇来说,口服L-素补充剂是可以接受的. 虽然它增加了关键的血管生物标志物,但在这个可行性试验中,它没有显著影响母亲的血压.
科学领域:
- 产科和妇科 产科和妇科
- 心血管研究研究心血管研究
- 营养科学 营养科学
背景情况:
- 补充L-氨酸可以改善血管健康并降低非孕妇和高血压孕妇小鼠的血压.
- 怀孕期间的慢性高血压带来风险,需要安全有效的干预措施来管理孕产妇和胎儿的结果.
- 了解L-氨酸在患有慢性高血压的孕妇的疗效和安全性,对于临床实践至关重要.
研究的目的:
- 评估诊断为慢性高血压的孕妇口服L-素补充剂的可接受性.
- 为了评估L-氨酸对孕妇血压 (BP) 和怀孕期间其他血管生物标志物的影响.
- 探索L-氨酸对子宫动脉多普勒流和血管原生生物标志物的影响.
主要方法:
- 一个早期的随机可行性试验,涉及患有慢性高血压的孕妇 (妊娠12-16周).
- 参与者被随机分配,每天两次接受3g的L-氨酸或安慰剂8周.
- 测量了母体血中素,素,不对称二甲基素 (ADMA),血压,子宫动脉多普勒和血管原生生物标志物的水平.
主要成果:
- 孕妇报告口服L-素补充剂的接受度很高.
- 补充L-氨酸增加了母亲的氨酸,氨酸和氨酸:ADMA比率的血水平,特别是在合规的参与者中.
- 没有观察到对透静血压,子宫动脉多普勒或血管原生生物标志物的显著影响;该研究不足以检测小BP变化.
结论:
- 口服L-氨酸被患有慢性高血压的孕妇接受得很好,并积极影响关键的血管代谢物.
- 观察到的氨酸:ADMA比率的增加不如非孕妇群体明显,这表明妊娠的药理动力学发生了变化.
- 建议在怀孕期间对L-氨酸进行进一步的药理动力学研究,以充分阐明其生物效应和潜在的治疗作用.
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