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Updated: Jul 15, 2025

PAR-CliP - A Method to Identify Transcriptome-wide the Binding Sites of RNA Binding Proteins
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PAR-CliP - A Method to Identify Transcriptome-wide the Binding Sites of RNA Binding Proteins

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KaScape:一种基于测序的方法,用于蛋白质-DNA结合亲和力的全球表征.

Hong Chen1, Yongping Xu1, Jianshi Jin2

  • 1State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, and Biomedical Pioneering Innovation Center (BIOPIC), Peking University, Beijing, 100871, China.

Scientific reports
|October 3, 2023
PubMed
概括

卡斯凯普是一种新的方法,用于选所有DNA序列的转录因子 (TF) 结合. 这种高通量方法全面地绘制了TF约束景观,揭示了中等和低亲和度的地点.

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相关概念视频

Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...
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