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Updated: Jul 15, 2025

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基于线性混合模型的差异基因表达分析纠正了用于研究定量特征的错误正值通胀

Shizhen Tang1,2, Aron S Buchman3, Yanling Wang3

  • 1Department of Human Genetics, Center for Computational and Quantitative Genetics, Emory University School of Medicine, Atlanta, GA, 30322, USA.

Scientific reports
|October 3, 2023
PubMed
概括

一个新的线性混合模型 (LMM) 准确地分析差异基因表达 (DGE) 在大型RNA测序数据集中的阿尔茨海默病 (AD) 特征. 这种方法提高了假阳性率,并识别了多种组织中重要的基因.

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