从土壤中提取的Aspergillus terreus中鉴定出的生物活性代谢物
Menna Fayek1, Hassan Y Ebrahim1, Mohamed S Abdel-Aziz2
1Pharmacognosy Department, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt.
AMB Express
|October 3, 2023
概括
这项研究从土壤中分离了Aspergillus terreus,确定了具有显著抗炎和抗菌活性的新型代谢物. 提取物和化合物显示出对SARS-CoV-2尖端蛋白结合的强烈抑制.
科学领域:
- 微生物学和天然产品化学
- 菌的二次代谢物研究.
- 药物的发现和开发.
背景情况:
- Aspergillus terreus以产生生物活性化合物而闻名.
- 土壤真菌是新型化学实体的丰富来源.
- 需要针对炎症和微生物感染的新疗法.
研究的目的:
- 隔离和识别来自土壤衍生的Aspergillus terreus菌株的二次代谢物.
- 为了评估提取物和净化化合物的生物活性.
- 探索这些天然产品的潜在治疗应用.
主要方法:
- 从土壤中分离和识别Aspergillus terreus. 在土壤中分离和识别.
- 使用HPLC/MS.提取和净化微生物代谢物.
- 使用ESI/MS和NMR光谱学的化合物的结构阐明.
- 在体外测定ACE2尖端蛋白结合抑制,抗炎活性和抗菌作用.
主要成果:
- 确定了一种新的甘油三和一种二基托皮佩拉衍生物 (阿斯),以及两种已知的丁洛拉克.
- 提取物和化合物显示出强烈抑制了ACE2-SARS-CoV-2尖端蛋白结合.
- 对IL-6和TNF-α观察到显著的抗炎作用.
- 针对金黄色葡萄球菌和白菌的抗菌活性被注意到.
结论:
- 来自Aspergillus terreus的二次代谢产物具有多样化和强大的生物活性.
- 这些发现凸显了真菌天然产品作为新型治疗剂来源的潜力.
- 需要进一步的研究来探索这些化合物的全部治疗潜力.
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