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在早产新生儿中发生支气管肺功能障碍的风险计算器:一项前性观察性研究
Medha Goyal1, Dwayne Mascarenhas2, Ruchi Nanavati1
1Department of Neonatology, Seth GS Medical College and King Edward Memorial Hospital, Parel, Mumbai, 400012, India.
Indian journal of pediatrics
|October 3, 2023
概括
这项研究发现,NICHD支气管肺形 (BPD) 风险估计器准确地预测了印度非常早产婴儿中中度至严重的BPD. 确定了BPD的主要风险因素,有助于早期干预策略.
科学领域:
- 新生儿医学 新生儿医学
- 儿科肺病学 儿科肺病学
- 临床流行病学临床流行病学
背景情况:
- 支气管肺功能障碍症 (BPD) 是非常早产婴儿患病的重要原因.
- 准确预测BPD对于及时干预和改善结果至关重要.
- 美国国家儿童健康与人类发展研究所 (NICHD) 的BPD风险估计器是一个经过验证的工具,但其在不同人群中的准确性需要评估.
研究的目的:
- 在一个非常早产的印度队伍中确定BPD的发病率和风险因素.
- 评估NICHD BPD风险估计器在预测该人口中的BPD风险估计器的准确性.
- 为了早期预测,在多个时间点评估估计器的性能.
主要方法:
- 一项前性观察性研究招募了310名早产新生儿 (怀孕23-30周).
- 分析了BPD的发病率和风险因素.
- 用NICHD BPD风险估计器来预测BPD,并将其准确性与观察到的结果进行比较.
主要成果:
- 任何BPD的发病率为17.4%,在出院前死亡率为32.3%.
- 严重的BPD风险因素包括败血症,PDA,ROP,IVH和输血.
- 该NICHD估计器在预测死亡或中度至重度BPD的第1天 (AUC 0.82) 和第3天 (AUC 0.77) 中表现出很好的准确性.
结论:
- NICHD BPD风险估计器是有效的早期预测中度至重度的BPD在印度早产婴儿.
- 确定特定的风险因素可以指导有针对性的管理策略.
- 这项研究证实了NICHD工具在南亚人口中的实用性.
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