抗血小板治疗模式和二次中风预防的结果在英国
Xuejun Liu1, Jenny Jiang1, Danshi Li1
1Bristol Myers Squibb, 3401 Princeton Pike, Lawrenceville, NJ, 08640, USA.
Cardiology and therapy
|October 3, 2023
概括
在英国,许多中风患者没有接受抗血小板治疗,以预防二次中风. 需要改进的抗血栓治疗方法来增加治疗率并改善患者的治疗结果.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 卒中是全球死亡和残疾的主要原因之一.
- 抗血小板治疗对于预防复发性缺血性中风 (IS) 和短暂性缺血性发作 (TIA) 是至关重要的.
- 本研究检查了抗血小板治疗模式和二次中风预防 (SSP) 的结果,在英国成年人没有心房的IS/TIA住院后.
研究的目的:
- 为了评估门诊抗血小板治疗模式.
- 评估治疗结果,包括中风复发,心肌梗塞,出血和死亡率.
- 识别二次中风预防策略中的潜在缺口.
主要方法:
- 使用英国临床实践研究数据链接和医院情节统计数据 (2011-2019) 的回顾性观察研究.
- 对抗血小板治疗的类型,持续时间和停止率的分析.
- 关键临床结果的评估:IS,心肌梗塞,严重出血和死亡率.
主要成果:
- 13.9%的住院患者在90天内没有接受抗血栓治疗.
- 克洛皮多格雷尔 (74.8%),阿司匹林 (16.7%) 和双抗血小板治疗 (DAPT,5.9%) 是常见的治疗方法.
- 观察到高停药率:36.9% (阿司匹林),43.3% (克洛皮多格雷尔),35.1% (DAPT) 在1年后.
- 与接受治疗的患者相比,未接受治疗的患者的IS率 (14.9vs6.5) 和死亡率 (39.8vs7.3) 显着更高.
结论:
- 很大一部分英国中风患者可能不会接受二次预防的抗血小板治疗.
- 目前的抗血小板策略 (克洛皮多格雷尔,阿司匹林,DAPT) 显示常见但变化的使用和坚持.
- 显然需要加强抗血栓治疗,以改善长期治疗坚持和患者在二次中风预防中的结果.
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