虫诱导的免疫对细菌或病毒感染的影响
Hong Chen1, Zengguo Cao2, Mingyuan Liu1,3
1State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.
Veterinary research
|October 3, 2023
概括
虫感染调节宿主免疫反应,影响对病毒和细菌等其他病原体的易感性. 本综述探讨了虫如何影响并发感染和SARS-CoV-2疾病的结果.
科学领域:
- 免疫学 免疫学 免疫学
- 病原体与宿主相互作用
- 传染病 传染病 传染病 传染病
背景情况:
- 细菌和病毒等病原体会触发I型免疫反应 (例如,IFN-γ,TNF-α,TH1细胞).
- 虫感染通常会引起II型免疫反应 (例如IL-4,IL-5,IL-13,TH2细胞),这些免疫反应可能与I型免疫反应相对抗.
- 虫感染可以改变宿主对其他病原体随后或同时感染的反应.
研究的目的:
- 审查当前关于虫感染如何影响微生物感染的知识.
- 讨论介导免疫对SARS-CoV-2疾病结果的影响.
主要方法:
- 关于虫感染和宿主免疫反应的研究文献综述.
- 对虫免疫反应调节的分析.
- 对并发感染和SARS-CoV-2的临床影响的讨论.
主要成果:
- 虫感染对宿主对病毒和细菌感染的反应有不同的影响.
- 了解虫诱导的免疫调节对于管理共感染至关重要.
- 介导免疫可能会影响SARS-CoV-2的严重程度和结果.
结论:
- 虫感染对宿主免疫力和对其他病原体的敏感性有重大影响.
- 需要进一步的研究来阐明虫,其他感染和宿主免疫之间的复杂相互作用,特别是在SARS-CoV-2的背景下.
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