门德尔的随机化分析显示,新鲜水果摄入量是抗尿病的保护因素
Yiwei Lin1, Cheng Zhou1,2, Yuqing Wu1
1Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, Zhejiang, China.
Human genomics
|October 3, 2023
概括
摄入新鲜水果和茶可以显著降低患结石的风险. 这项门德尔的随机化研究证实了新鲜水果摄入量与减少尿病风险之间的因果关系.
科学领域:
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 饮食因素与尿病风险有关.
- 以前的研究表明,食物摄入和结石形成之间存在关联.
- 因果关系需要严格的调查.
研究的目的:
- 调查各种食物摄入对尿病风险的因果关系.
- 利用门德尔的随机化来评估对饮食习惯的遗传倾向及其对结石发育的影响.
主要方法:
- 采用了一个双样本的门德尔随机化研究设计.
- 从英国生物银行GWAS数据中确定了食物摄入的遗传变异.
- 使用FinnGen联盟数据分析了与尿病的关联.
主要成果:
- 茶的摄入显示出对脏和尿道结石的保护作用 (OR=0.433).
- 新鲜水果摄入量显著降低了和尿道结石的风险 (OR=0.358).
- 在对维生素D和维生素C进行调整后,新鲜水果摄入的保护性关联仍然存在.
结论:
- 基因预测的新鲜水果摄入量与较低的结石风险有因果关系.
- 茶饮也可能起到降低尿病风险的作用.
- 这些发现支持预防结石的饮食建议.
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