人口组织不同阶段的多谱极化显微镜:一个极化研究研究
Priyanka Mann1, Pramila Thapa1, Vivek Nayyar2
1Bio-photonics and Green-photonics Laboratory, Department of Physics, Indian Institute of Technology Delhi, New Delhi, India.
Journal of biophotonics
|October 3, 2023
概括
多光谱极化成像为分析口腔组织提供了一种非侵入性方法. 这种技术揭示了线性双断率的显著变化,有助于早期检测口腔癌.
科学领域:
- 生物医学光学 生物医学光学
- 光学诊断器的光学诊断系统
- 癌症研究 癌症研究
背景情况:
- 极化成像是一种无标签,非侵入性的光学技术,对生物医学应用至关重要.
- 它可以对生物样本进行详细的研究,这对于诊断至关重要.
研究的目的:
- 为了研究口腔组织的基于多光谱偏振的成像.
- 在各种癌症阶段分析口腔组织的极度学特性.
主要方法:
- 使用极化显微镜系统与宽带光源用于口腔组织成像.
- 通过获取强度图像进行多谱斯托克斯映射.
- 获取的极化参数:极化程度,快速轴角,减速和线性双折.
主要成果:
- 在正常,癌前和癌症口腔组织中的量化线性双折射.
- 观察到线性双断率的显著增加:分别为 (1.7 ± 0.1) × 10−3, (2.5 ± 0.2) × 10−3和 (3.3 ± 0.2) × 10−3.
- 报告了多个波长的偏振元件的统计时刻.
结论:
- 多光谱极化成像有效地在癌症的不同阶段区分口腔组织.
- 线性双断变化是口腔癌检测和进展的关键指标.
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