糖尿病黄斑的发展与全身药物治疗有关 - 一项流行病学研究
Sirpa Loukovaara1,2, Ani Korhonen1, Leo Niskanen3
1Individualized Drug Therapy Research Program, University of Helsinki, Helsinki, Finland.
Acta ophthalmologica
|October 4, 2023
概括
这项研究发现,某些全身性药物与糖尿病黄斑 (DME) 风险有关. 一些药物可能会降低DME的发生率,而其他药物,如胰岛素和某些血压药物,会增加它.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病黄斑 (DME) 是糖尿病患者视力丧失的主要原因.
- 了解系统性药物在DME病变发生中的作用对于患者管理至关重要.
- 关于系统性药物与DME发病率的关系的大规模研究是有限的.
研究的目的:
- 确定系统性药物使用与糖尿病黄斑 (DME) 发病率之间的关联.
- 调查系统性药物对DME发育的潜在有益或有害影响.
主要方法:
- 一项历史上的队列研究利用了150,353名糖尿病患者的行政数据.
- 一个嵌套的病例控制设计,比较2630个DME病例与13144个控制.
- 条件后勤回归模型用于计算几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 肌痛性脑膜炎的发病率为每1000人/年1.80.
- 与男性相比,女性的DME发病率较低 (IRR为0.57).
- 与较低的DME风险相关的药物包括激素替代疗法雌激素,特马泽帕姆和阿洛普里诺.
- 与增加DME风险相关的药物包括胰岛素/类似物,硫尿素,罗西米德,安洛迪平,拉米普利和埃纳拉普利.
结论:
- 系统性药物与DME发病率有不同的关联,这表明它在病变发生过程中发挥了作用.
- 这些发现突出了糖尿病患者常见药物类别的潜在治疗目标和风险.
- 鼓励进一步的研究,以阐明系统性药物和DME之间的复杂相互作用.
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