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Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy
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可靠的,标准化的细胞机械性能测量

Sandra Pérez-Domínguez1, Shruti G Kulkarni1, Joanna Pabijan2

  • 1Institute of Biophysics, University of Bremen, 28359, Bremen, Germany. radmacher@uni-bremen.de.

Nanoscale
|October 4, 2023
PubMed
概括

一个新的标准化操作协议 (SOP) 允许使用原子力显微镜 (AFM) 进行癌细胞生物机械性质的可重复测量. 这一进步有助于将细胞软度作为临床诊断中的潜在诊断标记.

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Mechanical Protein Functions01:58

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Proteins perform many mechanical functions in a cell. These proteins can be classified into two general categories- proteins that generate mechanical forces and proteins that are subjected to mechanical forces. Proteins providing mechanical support to the structure of the cell, such as keratin, are subjected to mechanical force, whereas proteins involved in cell movement and transport of molecules across cell membranes, such as an ion pump, are examples of generating mechanical force. 
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