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Updated: Jul 15, 2025

Measuring Caspase Activity Using a Fluorometric Assay or Flow Cytometry
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cIAPs控制RIPK1激酶活动依赖和独立的细胞死亡和组织炎症

Fabian Schorn1, J Paul Werthenbach1, Mattes Hoffmann1

  • 1Faculty of Medicine and University Hospital of Cologne, Institute for Molecular Immunology, University of Cologne, Cologne, Germany.

The EMBO journal
|October 4, 2023
PubMed
概括

细胞亡抑制蛋白 (cIAP) 通过使RIPK1.1无处不在来调节TNF信号传递. 不活跃的cIAP1/2和RIPK1突变小鼠显示了cIAP对TNFR1毒性的控制,独立于RIPK1和RIPK3,为治疗研究提供了一个新的模型.

关键词:
在RIPK1中使用.这就是TNF TNF.cIAP1 的使用情况.在 cIAP2 中.在任何地方都是无处不在的.

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