双能量计算机断层扫描图像噪声在质子疗法治疗规划中的影响
Torbjörn Näsmark1, Jonas Andersson1
1Department of Radiation Sciences, Radiation Physics, Umeå University, SE-901 85 UMEÅ, Sweden.
Physics and imaging in radiation oncology
|October 4, 2023
概括
这项研究评估了用于质子停止功率映射的双能CT方法,发现噪声灵敏度有很大差异. 仔细评估这些方法对于精确的质子疗法至关重要,特别是随着利率的缩小.
科学领域:
- 医学物理 医学物理
- 辐射疗法 辐射疗法
- 图像处理 图像处理
背景情况:
- 质子疗法使用3.5%的范围不确定性边际,CT图像噪声贡献0.5%的假设.
- 双能CT (DECT) 提供了相对于水 (SPR) 映射的改善质子停止功率的潜力.
研究的目的:
- 为了评估基于DECT的三种SPR映射方法的噪声敏感性:Näsmark & Andersson (N&A),Landry-Saito (L-S) 和DirectSPR.
- 为了确定CT图像噪声对基于DECT的SPR计算中的质子范围不确定性的影响.
主要方法:
- 从两个供应商获得的DECT幻影数据,重复30次进行变异分析.
- 使用N&A,L-S和DirectSPR方法生成SPR地图.
- 在使用生成的SPR地图的治疗计划系统中模拟质子范围.
主要成果:
- L-S扩大了输入噪声;DirectSPR保持了噪声水平;N&A压缩了噪声,但显示了输入数据的灵敏度.
- 只有N&A在一个扫描仪上改善了0.5%的噪声贡献;所有方法在另一个扫描仪上都超过了0.5%.
- 虚拟单能图像减轻了噪音问题;增加辐射剂量有所帮助,而降低噪音的影响有限.
结论:
- 基于DECT的SPR映射中的噪音敏感性是质子疗法的关键因素.
- 在临床采用之前,准确的估计和对噪声敏感性的考虑是必不可少的,特别是在减少治疗边际的情况下.
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