严重,持续,破坏性疲劳后SARS-CoV-2不成比例地影响年轻女性
Jillian Kallman Price1, Leyla de Avila1, Maria Stepanova1,2,3
1Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, USA.
International journal of general medicine
|October 4, 2023
概括
后急性SARS-CoV-2 (PASC) 疲劳会影响福祉和功能,特别是在年轻的女性个体中,女性个体具有特定的健康史. 了解这种疲劳对于有效的长期COVID-19恢复策略至关重要.
科学领域:
- 医学研究 医学研究
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 后急性SARS-CoV-2 (PASC) 症状是持久的,难以治疗的.
- 疲劳是PASC的一个普遍和破坏性的症状,通常表明复苏困难.
- 了解PASC疲劳的特征对于患者管理至关重要.
研究的目的:
- 描述长期急性后SARS-CoV-2的自然史.
- 描述PASC的症状,重点关注疲劳.
- 确定与长期PASC和严重疲劳相关的风险概况.
主要方法:
- 在美国社区卫生系统中对SARS-CoV-2患者进行前性,纵向和观察性研究.
- 数据收集包括病史,症状报告和验证的患者报告结果 (PROs) 在入学和6个月后.
- 使用慢性疾病治疗功能评估-疲劳 (FACIT-F) 问卷对参与者的子集进行深入的疲劳评估.
主要成果:
- 临床上显著的疲劳报告了23.1%的参与者在基线.
- 严重的疲劳 (FACIT-F ≤29.7) 与年轻的年龄,女性性别,焦虑,抑郁和慢性脏疾病有关.
- 严重疲劳的人报告健康状况,饮食,体重和睡眠状况恶化,疲劳与PROs受损相关.
结论:
- 疲劳是COVID-19感染后的一个常见且显著的症状.
- 严重的疲劳与特定的人口统计和临床因素有关,包括年轻的年龄,女性性别,以及先前存在的疾病,如焦虑,抑郁和病.
- 疲劳对PASC患者的整体福祉和功能结果产生重大影响.
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