由丹诺苏马布引起的二次有机肺炎
Djalaleddine Ouakidi1, Bouchra Nesrine Bourouis1, Mohammed Amine Banat1
1Department of Pulmonology, Faculty of Medicine, University of Oran 1, Algeria.
European journal of case reports in internal medicine
|October 4, 2023
概括
骨质疏松症的药物德诺苏马布 (denosumab) 可能很少引起组织性肺炎,这是一种肺部疾病. 临床医生应监测这种潜在的肺毒性在患者治疗denosumab.
科学领域:
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
背景情况:
- 组织性肺炎是一种扩散性间歇性肺部疾病.
- 它可以是异常 (密码) 或二次的原因,如药物.
- 德诺苏马布是一种用于骨质疏松症的人类单克隆抗体,罕见的肺部不良反应报告.
研究的目的:
- 报告与denosumab相关的药物诱导的组织性肺炎病例.
- 提高临床医生的意识,以了解denosumab的潜在肺毒性.
主要方法:
- 一个用denosumab治疗的57岁严重骨质疏松症女性患者的案例研究.
- 临床表现包括急性呼吸困难,干咳和呼吸不良.
- 诊断工具包括高分辨率计算机断层扫描 (HRCT) 和排除感染/免疫病因.
主要成果:
- 患者在注射denosumab后表现出症状恶化.
- 在HRCT检测中发现了双边的基底帕伦基马凝结.
- 对皮质类固醇治疗的良好反应支持了药物诱导的组织性肺炎的诊断.
结论:
- 德诺苏马布是药物诱导的有组织性肺炎的潜在原因.
- 临床医生必须对这种罕见但严重的肺毒性保持警.
- 虽然这种情况表明存在联系,但确定的因果关系需要进一步调查.
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