CD19向的化学抗原受体T细胞疗法用于同时扩散大B细胞淋巴瘤和多发性髓瘤
Tyler D'Ovidio1, Kathryn Ciccolini1, Matko Kalac1
1Division of Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, USA.
Cureus
|October 4, 2023
概括
本病例报告详细介绍了一种罕见的同时发生多发性骨髓瘤 (MM) 和扩散性大B细胞淋巴瘤 (DLBCL) 的病例. 针对CD19的CAR T细胞疗法成功治疗了这两种血液性恶性瘤.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 多发性骨髓瘤 (MM) 和扩散性大B细胞淋巴瘤 (DLBCL) 是不同的血液恶性瘤.
- 在同一患者中MM和DLBCL同时发生是非常罕见的.
- 化学抗原受体 (CAR) 针对CD19或B细胞成熟抗原 (BCMA) 的T细胞疗法在血液癌症中显示出有效性.
研究的目的:
- 报告与CD19向的CAR-T细胞疗法治疗的第一例并发性MM和DLBCL病例.
- 在这种罕见的场景中描述临床表现和治疗结果.
主要方法:
- 通过骨髓活检证实MM的诊断,骨髓活检显示了兰巴受限血细胞.
- DLBCL的诊断证实了大腿质量的淋巴结活检.
- 用针对CD19的CAR T细胞疗法进行治疗.
主要成果:
- 这位患者出现了MM和DLBCL.
- 在针对CD19的CAR T细胞治疗后,该患者没有达到可检测的MM或DLBCL.
- 这代表了首次成功使用CAR T细胞治疗联合MM和DLBCL的记录案例.
结论:
- 针对CD19的CAR T细胞疗法可以在患有并发MM和DLBCL的患者中有效.
- 这一案例凸显了免疫治疗在治疗罕见的血液癌症组合中的潜力.
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