中国上海结核病传播动态的基因型和空间分析:为期10年的前性基于人口的监测研究
Meng Li1, Liping Lu2, Qi Jiang1,3
1Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Science, Shanghai Medical College, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China.
当地传播推动了上海的结核病 (TB).
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 基因组流行病学 基因组流行病学
背景情况:
- 中国的结核病发病率已经放缓下降,特别是在上海等大城市.
- 了解本地传播动态对于有效的结核病控制战略至关重要.
研究的目的:
- 在上海江区十年 (2011-2020年) 分析结核病的特征和传播模式.
- 确定影响结核病聚类和空间分布的因素.
- 为减少结核病负担提供有针对性的干预信息.
主要方法:
- 对培养阳性肺结核患者的基于人口的研究.
- 全基因组测序以定义基因组集群 (≤12个单核酸多态).
- 用于风险因素分析的物流回归和用于传输推理的phybreak.
主要成果:
- 国内移民占结核病病例的74.7%,结核病发病率较高,但结核病聚集率低于居民.
- 聚类与男性移民,年轻人以及体力劳动者有关.
- 居民和移民之间的传播是有限的,居民更常向移民传播.
结论:
- 当地,最近的传播,而不仅仅是进口病例,对上海移民人口的结核病负担作出了重大贡献.
- 需要新的策略来早期检测结核病并中断城市传播途径.
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