弗里德瓦尔德公式可用于从LDL-C和TG中计算非HDL-C
Jerzy Romaszko1, Leszek Gromadziński2, Adam Buciński3
1Department of Family Medicine and Infectious Diseases, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland.
Frontiers in medicine
|October 4, 2023
概括
修改后的弗里德瓦尔德公式可以通过使用LDL胆固醇和甘油三来估计非HDL胆固醇. 这种方法为心血管风险评估提供了一个更简单,可能更具成本效益的替代方案.
科学领域:
- 临床化学 临床化学
- 评估心血管风险评估
- 脂质代谢 脂质代谢是什么
背景情况:
- 弗里德瓦尔德公式 (FF) 由于其简单性,一直是估计LDL胆固醇 (LDL-C) 的长期方法.
- 目前欧洲心脏病学会的指导方针使用非高密度胆固醇 (非高密度胆固醇-C) 来评估心血管风险,通常需要测量总胆固醇 (TC) 和高密度胆固醇 (HDL-C).
- 直接的LDL-C测量方法现在已经广泛使用,但更简单的估计技术仍然很重要.
研究的目的:
- 建议修改弗里德沃尔德公式,使用LDL胆固醇 (LDL-C) 和甘油三 (TG) 值计算非高密度胆固醇 (非高密度胆固醇-C).
- 与标准实验室测量相比,评估本拟议方法的准确性.
- 探索降低脂质检测成本的潜力.
主要方法:
- 一个包含26,914个完整脂质面板实验室结果的数据库的分析.
- 使用标准方法 (需要TC和HDL-C) 和拟议的修改FF (使用LDL-C和TG) 来计算非HDL-C.
- 计算和测量非HDL-C值之间的百分比误差的确定.
主要成果:
- 使用FF计算的LDL-C的平均误差为9.77%,与测量的LDL-C相比.
- 使用拟议方法计算的非HDL-C的平均误差为8.88%,与测量的非HDL-C相比.
- 计算的LDL-C和非HDL-C都与各自的测量值有很强的相关性 (r=0.965和r=0.962).
结论:
- 通过使用LDL胆固醇和甘油三水平,可以准确计算非HDL胆固醇,从而不需要TC和HDL-C测量.
- 这种修订的计算方法有可能显著降低脂质资料测试的成本.
- 拟议的方法为估计非HDL-C提供了切实可行的替代方案,支持其在心血管风险评估中的使用.
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