白细胞细胞群数据作为COVID-19疾病特征的潜在标志物
Giovanni Introcaso1, Arianna Galotta2, Laura Salvini3
1Università di Milano, Centro Cardiologico Monzino IRCCS, Unit of Laboratory Medicine, Milan, Italy.
Journal of medical biochemistry
|October 4, 2023
概括
白细胞细胞群数据 (CPD) 在早期COVID-19浪潮中显示细胞活化增加,表明临床状况更差. 这些血液学参数可以作为评估风险的有价值的疾病标志物.
科学领域:
- 血液学 血液学 血液学
- 在COVID-19研究研究中.
- 临床诊断 临床诊断 临床诊断
背景情况:
- 血液学参数对于了解COVID-19至关重要.
- 目前正在探索白细胞细胞群数据 (CPD) 的临床意义.
- 之前的研究强调了在COVID-19大流行期间血液学参数的重要性.
研究的目的:
- 在SARS-CoV-2患者中评估细胞群数据 (CPD).
- 评估CPD作为COVID-19潜在的新型疾病标志物.
- 为了比较COVID-19流行病的不同波段之间的CPD.
主要方法:
- 在第一波 (2020年2月至4月) 招募了540名患者,第二波 (2020年9月至12月) 招募了2821名患者.
- 通过使用多重式rRT-PCR.诊断出SARS-CoV-2.
- 用Sysmex XN 2000血液学分析仪分析了CPD,并测量了C反应蛋白 (CRP) 和乳酸脱酶 (LDH).
主要成果:
- 与参考群体相比,在两波波中观察到所有细胞类型的CPD增加.
- 在第一波中发现9个CPD升高,而在第二波中发现5个.
- 与第二波相比,第1波中发现的CPD值 (NE-SFL,LY-Y,LY-Z,MO-X,MO-Y),CRP和LDH显著更高.
结论:
- 在第一波患者中,CPD显示细胞活化升高,与较差的临床结果相关.
- 慢性病发症作为有效的标志物用于COVID-19的疾病特征.
- 慢性病发症在开发COVID-19患者的风险模型方面显示出潜在的实用性.
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