通过准FoxO1,Lncrna CASC11会使糖尿病病恶化
Yun Zhang1, Shuhan Shi1, Changda Lin1
1Second Affiliated Hospital of Fujian Medical University, Department of Renal Medicine, Quanzhou, China.
Journal of medical biochemistry
|October 4, 2023
概括
循环RNA CASC11通过调节分叉转录因子O1 (FoxO1) 来加剧糖尿病病 (DN). 这项研究研究了CASC11在DN病变发生中的作用及其与FoxO1.1的关联.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 糖尿病病 (DN) 是糖尿病的一种严重并发症.
- 循环RNA CASC11在DN进展中的作用尚未完全理解.
- 叉头转录因子O1 (FoxO1) 涉及DN病变的发生.
研究的目的:
- 调查CASC11在加重DN的生物效应.
- 探索DN中CASC11和FoxO1之间的监管关系.
- 评估CASC11作为DN发病的潜在生物标志物.
主要方法:
- 在DN患者中测量了血清CASC11和FoxO1水平.
- 接收器操作特征 (ROC) 曲线分析了CASC11对DN的预测值.
- 皮尔森相关性评估了CASC11和FoxO1.1之间的关系.
- 在体外实验中,研究了高葡萄糖诱导的中细胞中的细胞增殖和迁移.
- 西方斑点分析了TGF-β1和Smads的蛋白质水平.
主要成果:
- 在DN患者中,血清CASC11水平发生显著变化.
- CASC11显示出预测DN发病的潜力.
- 在CASC11和FoxO1水平之间观察到显著的相关性.
- CASC11和FoxO1的干预影响了脏中细胞的增殖和迁移.
- CASC11和FoxO1调节了TGF-β1和Smad蛋白的表达.
结论:
- CASC11在加重DN方面发挥着至关重要的作用,部分是通过调节FoxO1.1来调节.
- CASC11可以作为DN的潜在诊断生物标志物.
- 准CASC11和FoxO1可以为DN提供治疗策略.
相关概念视频
lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
NF-κB-dependent Signaling Pathway
7.5K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.5K
Non-Canonical Wnt Signaling Pathways
7.3K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.3K
Canonical Wnt Signaling Pathway
8.8K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
8.8K
Notch Signaling Pathway
4.3K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.3K
Pathophysiology of Diabetes
971
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
971


