多模态磁共振成像对主观认知衰退中的大脑结构和功能变化:一个迷你回顾
Jinhuan Yue1,2, Shengwang Han3, Ang Li4
1Shenzhen Frontiers in Chinese Medicine Research Co., Ltd., Shenzhen, China.
Frontiers in aging neuroscience
|October 4, 2023
概括
识别主观认知衰退 (SCD),阿尔茨海默病 (AD) 的早期阶段,至关重要. 这项研究使用MRI技术发现大脑变化,有助于早期SCD诊断和干预.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 主观认知衰退 (SCD) 是阿尔茨海默病 (AD) 最早的症状阶段.
- 早期发现SCD及其相关风险因素对于及时进行旨在延缓AD进展的干预至关重要.
- 现有的研究广泛利用各种神经成像模式,包括结构性MRI (sMRI),扩散张力成像 (DTI) 和功能性MRI (fMRI),用于SCD研究.
研究的目的:
- 调查与主观认知衰退 (SCD) 相关的结构和功能性大脑异常.
- 探索用于诊断SCD的先进神经成像技术的潜力.
- 为早期识别患有阿尔茨海默病风险的个体作出贡献.
主要方法:
- 结构磁共振成像 (sMRI) 的应用来评估大脑结构.
- 使用功能磁共振成像 (fMRI) 来评估大脑功能.
- 对SCD研究中神经成像近期进展的文献综述.
主要成果:
- 在SCD患者中使用sMRI识别了特定的异常大脑结构.
- 在SCD参与者中通过fMRI检测到大脑功能模式的改变.
- 研究结果表明,SCD有不同的神经成像生物标志物.
结论:
- 在认知衰退的早期阶段,可以检测到结构性和功能性大脑变化.
- sMRI和fMRI作为主观认知衰退的诊断工具具有前景.
- 基于神经成像的早期诊断可以促进针对性干预,以预防阿尔茨海默病.
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