用活生生的小鼠肺炎病毒载体的SARS-CoV-2疫苗进行粘膜主要增强免疫接种,对有保护作用
Ursula Buchholz1, Jaclyn Kaiser1, Christine Nelson2
1NIH.
Research square
|October 4, 2023
概括
用活衰减的小鼠肺炎病毒载体 (MPV/S-2P) 进行呼吸道免疫,表达SARS-CoV-2尖端蛋白,显示出高免疫性. 两个剂量为 rhesus 提供了对 SARS-CoV-2 挑战的完全保护.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 目前正在探索呼吸道免疫策略,以提高SARS-CoV-2疫苗的有效性.
- 活体减弱病毒载体为粘膜疫苗接种提供了一个有前途的平台.
结论:
- 用活衰减的MPV载体进行粘膜原始/增强免疫是非常有效的策略.
- 这种方法可以防止SARS-CoV-2感染和复制,提供一个有前途的疫苗候选人.
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