在血流感染中识别和向微生物布素乙化
Jared R Mayers1,2,3, Jack Varon1,2, Ruixuan R Zhou4
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA 02115.
bioRxiv : the preprint server for biology
|October 4, 2023
概括
研究人员发现了一种细菌酶,SpeG,在格拉姆阴性血流感染期间产生N-乙丁素. 阻断SpeG通过增加抗生素吸收来对抗抗菌素耐药性,提供新的治疗策略.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 代谢学 代谢学 代谢学
背景情况:
- 抗菌素耐药性 (AMR) 需要新的治疗点.
- 感染期间的细菌代谢仍未得到充分研究.
- 格拉姆阴性血流感染 (BSI) 显著改变宿主代谢.
结论:
- 针对细菌新陈代谢,特别是SpeG,提供了一种有前途的抗AMR策略.
- 在体内研究病原体代谢揭示了临床干预的新途径.
- 通过调节细菌代谢途径,可以在グラム阴性感染中克服AMR.
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