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Updated: Jul 15, 2025

The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress
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The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress

Published on: October 31, 2016

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低剪在短期影响内皮细胞的伸缩和对齐在长期的影响

Mohanish K Chandurkar1,2, Nikhil Mittal1,2, Shaina P Royer-Weeden1,2

  • 1Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931.

bioRxiv : the preprint server for biology
|October 4, 2023
PubMed
概括

暴露于短暂低剪压的内皮细胞 (ECs) 显示出增强的引和对齐,影响血管健康. 这种早期的机械体验塑造了长期内皮细胞行为和心血管疾病风险.

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Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
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Intracellular Signaling Affects Focal Adhesions

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Tension Response at Adherens Junctions

The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
α-Catenin as a Mechanosensory Protein
The α-catenin of adherens junctions is an allosteric protein with three VH (vinculin...
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