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在NIH-AARP饮食和健康研究中,诊断前的饮食模式和多发性骨髓瘤风险

Francesca Castro¹, Richa Parikh², Jelyn C Eustaquio³

¹Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center.

medRxiv : the preprint server for health sciences

|October 4, 2023

概括

健康的植物性饮食可以降低多发性骨髓瘤 (MM) 的风险. 这项大型研究表明,饮食选择可以影响MM发病率,帮助患者和医生做出决定.

科学领域:

流行病学流行病学
营养科学营养科学
在瘤学瘤学.

背景情况:

关于饮食模式和多发性骨髓瘤 (MM) 风险的研究有限.
以前的研究表明,素食/素食饮食可能会降低MM风险.
一项研究表明,与高的实证饮食炎症模式相关的MM风险增加.

研究的目的:

调查诊断前饮食模式与MM发病率之间的关联.
评估四个饮食指数:健康饮食指数-2015 (HEI-2015),健康饮食得分 (HDS),地中海饮食替代 (aMED) 和健康的植物性饮食指数 (hPDI).

主要方法:

来自NIH-AARP饮食和健康研究 (1995-2011) 的567,169名参与者的前性队列研究.
通过食物频率调查问卷评估饮食模式;得分计算并分成四分位数.
多变量Cox比例危险模型用于估计危险比率 (HR) 和95%置信区间 (95%CI),经过调整以考虑混因素.

主要成果:

在392589名参与者中,共发现了1366例MM病例.
较高的健康植物性饮食指数 (hPDI) 得分与MM风险降低显著相关 (HR 0.85;95%CI 0.73-1.0;p=0.043).
2015年HEI,HDS和aMED得分显示,与MM风险没有显著的关联.

结论:

健康的植物性饮食与减少多发性骨髓瘤的风险有关.
这些发现支持患者和瘤学家在MM风险方面做出明智的饮食选择.
这是迄今为止关于诊断前饮食模式和MM风险的最大的流行病学研究.

关键词:

饮食饮食饮食饮食饮食模式饮食模式多发性骨髓瘤是多发性骨髓瘤的一种.营养营养营养营养营养血细胞疾病血细胞疾病

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