和中风后的多基因风险
medRxiv : the preprint server for health sciences
|October 4, 2023
概括
遗传倾向增加了中风或过渡性缺血性发作 (TIA) 幸存者患中风后 (PSE) 的风险. 这项研究开发了一种多基因风险评分 (PRS),以确定患PSE风险较高的个体.
科学领域:
- 神经遗传学 神经遗传学
- 发病学 (Epileptology) 是一个专业的学科.
- 脑卒中医学 脑卒中医学
背景情况:
- 是高度遗传的,但急性脑损伤后的遗传基础,特别是中风后 (PSE),尚未研究.
- 了解遗传倾向对于识别患上中风或过渡性缺血性发作 (TIA) 后风险较高的个体至关重要.
研究的目的:
- 调查更高的遗传倾向性是否会增加中风/TIA幸存者患PSE的风险.
- 开发和验证用于预测PSE风险的多基因风险评分 (PRS).
主要方法:
- 进行了三阶段的遗传分析,识别了相关的遗传变异,并估计了特定于PSE的变异重量.
- 使用英国生物库数据构建了多基因风险评分 (PRS),并在"我们所有人"研究计划队列中测试了与PSE风险的关联.
- 分析包括多变量后勤回归,对相关共变量进行调整,基于祖先和敏感性分析的初级和二级分析,不包括TIA幸存者.
主要成果:
- 多基因风险评分 (PRS) 与所有我们队列中中风/TIA幸存者的PSE患病概率增加有显著关联 (OR:1.16[1.02-1.32]).
- 当分析仅限于欧洲祖先的参与者时 (OR:1.23[1.02-1.49]) 和当排除TIA幸存者时 (OR:1.18[1.02-1.38]),这种关联仍然是一致的.
结论:
- 遗传倾向在PSE的发展中起着重要作用,类似于其他形式的.
- 这些发现表明,PRS可以成为评估PSE遗传风险的有价值工具,尽管由于数据稀疏性,结果应该谨慎解释.
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