相关实验视频

Updated: Aug 7, 2026

Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing

Generation of Microtumors Using 3D Human Biogel Culture System and Patient-derived Glioblastoma Cells for Kinomic Profiling and Drug Response Testing

Published on: June 9, 2016

一个预后矩阵代码定义了功能性质母细胞瘤表型和位

Monika Vishnoi^1,2, Zeynep Dereli³, Zheng Yin⁴

¹Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, 77030 USA.

Research square

|October 4, 2023

概括

质母细胞瘤 (GBM) 基因表达定义了与患者生存和免疫细胞透相关的瘤亚型. 一个17基因特征可以预测对PD1阻断疗法的反应.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
基因组学就是基因组学.

背景情况:

瘤,免疫和血管之间的相互作用在质母细胞瘤 (GBM) 恶性瘤和治疗耐药性方面至关重要.
细胞外矩阵蛋白 (CMP) 在 GBM 内调解这些相互作用的组成和作用尚未完全理解.

结论:

CMP的"矩阵代码"为GBM异质性和进展提供了洞察力.
母体体基因表达模式可以识别具有明显临床结果和免疫微环境的GBM亚型.
这项研究提供了优化质母细胞瘤治疗策略的潜在生物标志物,包括免疫疗法.

更多相关视频

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy

Published on: October 4, 2019

相关概念视频

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...