暴露在重金属,肥胖和中风死亡率在美国
Ziqin Cao1, Kelly M Bakulski1,2, Henry L Paulson2,3
1Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA, 48109.
medRxiv : the preprint server for health sciences
|October 4, 2023
概括
血中和水平升高与中风死亡风险增加有关. 与肥胖患者相比,这些关联在正常体重或超重个体中更强.
科学领域:
- 环境健康 环境健康
- 心血管流行病学心血管流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 接触重金属,特别是和,是一个全球性公共卫生问题.
- 了解环境毒素与心血管疾病死亡率之间的联系对于预防策略至关重要.
研究的目的:
- 调查血液中和度与中风死亡率之间的关联.
- 检查肥胖对这些关联的潜在影响修改.
主要方法:
- 分析了来自国家健康和营养检查调查 (NHANES 1999-2016) 的23437名成年人 (40岁以上) 的数据.
- 将NHANES数据与国家死亡指数联系起来,以对中风相关死亡率进行随访 (中位数为8.3年).
- 经过对混因素进行调整的统计分析,包括金属度每倍增加的危险比率 (HRs).
主要成果:
- 较高的血和度与中风死亡率的增加显著相关.
- 金属度每倍的危险比为的1.16 (95% CI:1.11,1.20) 和的1.31 (95% CI:1.26,1.36).
- 与肥胖个体相比,在正常体重或超重个体中观察到更强的关联.
结论:
- 血中和水平升高是中风死亡率的重要风险因素.
- 肥胖可能会减轻重金属暴露和中风死亡率之间的关联.
- 公共卫生倡议应考虑减少环境重金属,以减轻心血管风险.
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