在肺部恶化后预测肺功能恢复使用囊性纤维化呼吸道症状日记-慢性呼吸道感染症状尺度
Eliana R Gill1, Christopher H Goss1, Scott D Sagel2
1University of Washington.
Research square
|October 4, 2023
概括
在患有囊性纤维化 (PwCF) 的人群中,肺部恶化 (PEx) 开始时的高症状负担预示着无法恢复到基线肺功能. 监测慢性呼吸道感染症状尺度 (CRISS) 可以识别有风险的PwCF.
科学领域:
- 肺部医学 肺部医学
- 囊性纤维化研究 囊性纤维化研究
- 症状负担评估 症状负担评估
背景情况:
- 囊性纤维化 (PwCF) 患者的肺恶化 (PExs) 会导致显著的医疗费用和肺功能下降.
- 症状负担是疾病状况的关键指标,可以预测PwCF的长期结果.
- 早期识别患有持续肺功能下降风险的PwCF对于及时干预至关重要.
研究的目的:
- 为了确定PEx发作时症状负担的严重程度是否预测无法恢复基线肺功能.
- 调查囊性纤维化呼吸道症状日记 (CFRSD) - 慢性呼吸道感染症状量表 (CRISS) 在预测PEx结果中的实用性.
主要方法:
- 一项纵向观察性研究的二次分析 (N=56).
- 在基线收集的数据,PEx诊断 (访问1),PEx期间 (访问2),以及住院后 (访问3).
- 线性回归模型用于分析CRISS得分与肺功能恢复之间的关系.
主要成果:
- 一个回归模型表明,对于CRISS得分的每一个点的增加,肺功能恢复减少了0.2点.
- 具有CRISS分数>48.3的PwCF在第二次访问时没有恢复到基线肺功能的风险高出14%.
- 在PEx发作时较高的症状负担与较差的肺功能恢复有关.
结论:
- 在PEx发作时监测CRISS得分是一种有效的,非侵入性的方法来评估PwCF状态.
- 在PwCF中PEx期间评估症状负担对于预测临床结果非常有价值.
- 这些发现支持在肺部恶化期间使用症状监测来管理PwCF.
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