安慰剂治疗会影响与情感和认知过程相关的大脑系统,但不会影响感知性疼痛
Rotem Botvinik-Nezer1,2, Bogdan Petre2, Marta Ceko3
1Hebrew University of Jerusalem.
bioRxiv : the preprint server for biology
|October 4, 2023
概括
安慰剂镇痛,一种强大的止痛效应,并没有显著改变感知性大脑活动. 相反,安慰剂对疼痛的影响是由与动机和价值相关的大脑区域的变化驱动的.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 心理学 心理学 心理学
背景情况:
- 安慰剂止痛是一种记录良好的现象,但它对 nociceptive 处理的影响仍在争论中.
- 以前的研究和元分析表明,对核心疼痛信号通路的影响有限.
研究的目的:
- 为了研究安慰剂止痛的神经机制.
- 为了确定安慰剂止痛药是否调节可感知大脑区域.
- 为了检查对热和机械疼痛的安慰剂效应.
主要方法:
- 有392名参与者的大型fMRI研究.
- 在安慰剂下对有害刺激的反应中对大脑活动的分析.
- 研究的预定义疼痛特征:神经疼痛特征 (NPS) 和刺激强度独立疼痛特征 (SIIPS).
主要成果:
- 安慰剂治疗对热和机械疼痛产生了强大的镇痛作用.
- 在初级感知性疼痛区域 (NPS,脊othalamic通路) 中没有观察到fMRI活性显著下降.
- 在SIIPS和与动机和价值相关的大脑区域的安慰剂调节活动.
结论:
- 安慰剂镇痛主要涉及情感和认知调制,而不是直接抑制感觉.
- 动机和价值回路中的神经变化与安慰剂缓解疼痛的个体差异相关.
- 研究结果强调了在安慰剂疼痛调节中心理因素和大脑机制之间的复杂相互作用.
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