估计抗生素消费的变化随着多西环林在美国的暴露后预防的引入
Kirstin I Oliveira Roster1, Yonatan H Grad1
1Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston MA.
medRxiv : the preprint server for health sciences
|October 4, 2023
概括
暴露后的多西环林 (doxy-PEP) 显著降低了关键人群的性传播疾病风险. 然而,广泛使用可能会使美国的抗生素消费量每月增加数百万剂量.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 抗微生物药物管理委员会
背景情况:
- 淋病,克拉米迪亚和梅毒等性传播感染 (STD) 构成了重大的公共卫生挑战.
- 多西环素暴露后预防 (doxy-PEP) 已证明有效降低与男性发生性关系的男性 (MSM),跨性别女性 (TGW) 和艾滋病毒感染者 (PLWH) 之间的性传播感染率.
- 人们担心,多西环林的使用可能会增加,从而导致抗菌素耐药性.
结论:
- 多克西-PEP是预防性病的有价值策略,特别是在高风险人群中.
- 多克西-PEP的广泛实施与整体抗生素消费量大幅增加有关.
- 为了平衡性传染病预防的好处与抗菌素耐药性的风险,需要仔细考虑处方策略和监测.
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