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使用生物信息学方法识别CDT1作为人类肺腺癌的预后标志物

Jing Jiang^1,2, Yu Zhang³, Jun Wang⁴

¹Department of Oncology, Hangzhou Traditional Chinese Medicine (TCM) Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.

|October 4, 2023

概括

CDT1 (染色体许可和DNA复制因子1) 的高表达表明肺腺癌 (LUAD) 的预后不佳. 这项研究将CDT1确定为LUAD的潜在生物标志物,表明它可能是治疗点.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

肺腺癌 (LUAD) 是全球癌症死亡的主要原因.
染色体许可和DNA复制因子1 (CDT1) 在细胞循环调节中发挥作用,并与各种癌症有关.
在LUAD中CDT1的预后意义尚未得到充分确立.

研究的目的:

为了研究在LUAD组织中CDT1的表达水平.
为了评估CDT1在LUAD患者的预后和诊断价值.
探索CDT1在LUAD进展中的作用背后的潜在机制.

主要方法:

使用TCGA和GEO数据库进行生物信息学分析.
基因本体学 (GO) 和KEGG通路分析.
卡普兰-梅尔生存分析,考克斯回归,qPCR和免疫组织化学.

主要成果:

与正常的肺组织相比,LUAD组织中CDT1表达显著上调.
高CDT1表达与患者生存率差相关,是独立的预后因素.
CDT1表达与细胞循环调节和免疫细胞透在LUAD中有关.

结论:

CDT1在LUAD上升调节,并作为预测不良预后的指标.
CDT1具有作为诊断生物标志物和LUAD治疗点的潜力.
对CDT1的机制的进一步研究可以为LUAD治疗策略提供信息.

关键词:

生物信息学分析生物标志物生物标志物 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 CDT1 肺部腺癌瘤是肺部腺癌.预测预后预测预测

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相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...