型肝炎病毒感染与肝外恶性瘤之间的关系
Hala I Mohamed1, Ehab M Abdelrahim1, Amr M Elsayed1
1Tropical Medicine Department, Faculty of Medicine, Minia University, Egypt.
Clinical and experimental hepatology
|October 4, 2023
概括
肝炎C病毒 (HCV) 感染与患肺癌,结肠直肠癌,胰腺癌和乳腺癌的风险更高有关. HCV阳性也减少了结直肠和胰腺癌患者的存活率.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 肝炎C病毒 (HCV) 是全球肝脏疾病的主要原因之一.
- 新出现的证据表明,HCV与非肝癌之间存在联系.
- 这项研究调查了HCV和肝外恶性瘤之间的关联.
研究的目的:
- 为了确定HCV血清阳性与肝癌外癌症的发展是否相关.
- 评估HCV血清阳性对不同类型癌症患者存活时间的影响.
主要方法:
- 一项回顾性病例对照研究,将1476名癌症患者 (肺癌,结肠直肠癌,胰腺癌,乳腺癌) 与1550名匹配对照患者进行比较.
- 对癌症患者与对照患者的HCV血清阳性率的分析.
- 在癌症子组内基于HCV血清状态的生存结果的比较.
主要成果:
- 与对照组 (7.3%) 相比,HCV血清阳性在整体癌症组 (11.6%) 中显著更高.
- 在肺癌 (20.1%),结直肠癌 (11.8%),胰腺癌 (25.4%) 和乳腺癌 (8.1%) 组中观察到升高的HCV血清阳性.
- 在结直肠癌和胰腺癌中,HCV血清阳性与生存率降低相关,但在肺癌或乳腺癌中没有显著的相关性.
结论:
- 肝炎病毒病毒阳性与患肺癌,结直肠癌,胰腺癌和乳腺癌的风险增加有关.
- 冠状病毒感染对结肠直肠癌和胰腺癌患者的存活率产生负面影响.
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